Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics

Author:

Farmer Aaron R.,Murray Clinton K.,Driscoll Ian R.,Wickes Brian L.,Wiederhold Nathan,Sutton Deanna A.,Sanders Carmita,Mende Katrin,Enniss Brent,Feig James,Ganesan Anuradha,Rini Elizabeth A.,Vento Todd J.

Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmedPythium aphanidermatumwound infection. Antemortem histopathology suggested disseminatedPythiuminfection, including brain involvement; however, postmortem PCR revealedCunninghamella elegans,Lichtheimia corymbifera, andSaksenaea vasiformiscoinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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