Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction-Reference-Cited by-同舟云学术

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction

Published:2023-02-28 Issue:2 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Duran-Castells Clara¹²,Llano Anuska¹,Kawana-Tachikawa Ai³^ORCID,Prats Anna⁴,Martinez-Zalacain Ignacio⁵,Kobayashi-Ishihara Mie⁶,Oriol-Tordera Bruna¹²,Peña Ruth¹,Gálvez Cristina¹,Silva-Arrieta Sandra¹,Clotet Bonaventura¹⁴⁷,Riveira-Muñoz Eva¹,Ballana Esther¹^ORCID,Prado Julia G.¹⁸⁹,Martinez-Picado Javier¹⁷¹⁰⁹^ORCID,Sanchez Jorge¹¹,Mothe Beatriz¹⁴⁷⁹^ORCID,Hartigan-O’Connor Dennis¹²,Wyss-Coray Tony¹³,Meyerhans Andreas⁶¹⁰,Gisslén Magnus¹⁴¹⁵,Price Richard W.¹⁶,Soriano-Mas Carles⁵¹⁷¹⁸,Muñoz-Moreno José Antonio⁴¹⁹,Brander Christian¹⁷¹⁰⁹,Ruiz-Riol Marta¹⁹^ORCID

Affiliation:

1. IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, Badalona, Spain

2. Departament de Biologia, Cel·lular, Fisiologia i d’immunologia, Facultat de Medicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain

3. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

4. Fundació Lluita contra la Sida and Infectious Diseases Department, Hospital Germans Trias i Pujol, Badalona, Spain

5. Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain

6. Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain

7. Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain

8. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

9. CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

10. ICREA, Barcelona, Spain

11. Centro de Investigaciones Tecnologicas Biomedicas y Medioambientales, CITBM, Lima, Peru

12. Department of Medical Microbiology and Immunology, University of California, Davis, California, USA

13. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA

14. Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

15. Region Västra Götaland, Sahlgrenska University Hospital, Department of Infectious Diseases, Gothenburg, Sweden

16. Department of Neurology, University of California San Francisco, San Francisco, California, USA

17. Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

18. Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain

19. Faculty of Psychology and Education Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain

Abstract

Neurocognitive disorders are frequently reported in people living with HIV (PLWH) even with the introduction of combined antiretroviral treatment (cART). To identify biomarkers and potential therapeutic tools to target HIV infection in peripheral blood and in the central nervous system (CNS), plasma proteomics were applied in untreated chronic HIV-infected individuals with different levels of virus control.

Funder

Ministerio de Ciencia e Innovación

MEC | Instituto de Salud Carlos III

HHS | NIH | NIH Clinical Center

Institució Catalana de Recerca i Estudis Avançats

Grifols

European Commission

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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