Membrane-Associated and Secreted Forms of the Rhesus Macaque Rhadinovirus-Encoded CD200 Homologue and Cellular CD200 Demonstrate Differential Effects on Rhesus Macaque CD200 Receptor Signaling and Regulation of Myeloid Cell Activation-Reference-Cited by-同舟云学术

Membrane-Associated and Secreted Forms of the Rhesus Macaque Rhadinovirus-Encoded CD200 Homologue and Cellular CD200 Demonstrate Differential Effects on Rhesus Macaque CD200 Receptor Signaling and Regulation of Myeloid Cell Activation

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Estep Ryan D.¹,Govindan Aparna N.¹,Fitzpatrick Kristin¹,Blair Tiffany C.¹,Rezaee S. A. Rahim²^ORCID,Blackbourn David J.³,Wong Scott W.¹⁴⁵

Affiliation:

1. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA

2. Immunology Research Center, Immunology Department, Ghaem Hospital, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

3. School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom

4. Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, USA

5. Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA

Abstract

Viral CD200 homologues are encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV) and the closely related rhesus macaque rhadinovirus (RRV). Though RRV viral CD200 (vCD200) has been examined, questions still exist in regard to the ability of this molecule to induce signaling via rhesus macaque CD200 receptor (CD200R) as well as the potential function of a secreted form of vCD200.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01654-20

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