Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s-Reference-Cited by-同舟云学术

Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yui Eto Karina¹²³,Firth Neville⁴,Davis Amy M.²³,Kwong Stephen M.⁴,Krysiak Marcelina²³,Lee Yung Thin⁵,O’Brien Frances G.²³,Grubb Warren B.²³,Coombs Geoffrey W.⁵,Bond Charles S.¹,Ramsay Joshua P.²³^ORCID

Affiliation:

1. School of Molecular Sciences, University of Western Australia, Crawley, WA, Australia

2. Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia

3. School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA, Australia

4. School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia

5. Antimicrobial Resistance and Infectious Disease Research Laboratory, Murdoch University, Perth, WA, Australia

Abstract

Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (WA), WA-5, encoded cadmium, tetracycline, and penicillin resistance genes on plasmid pWBG753 (∼30 kb).

Funder

Department of Health | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01560-19

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