Highly Conserved gsc1 Gene of Pneumocystis jirovecii in Patients with or without Prior Exposure to Echinocandins-Reference-Cited by-同舟云学术

Highly Conserved gsc1 Gene of Pneumocystis jirovecii in Patients with or without Prior Exposure to Echinocandins

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bonnet Pierre L.¹²,Le Gal Solène¹²,Hoffmann Claire V.¹²,Morio Florent³⁴,Diabira Fouleymata²,de Quélen Athéna²,Curral Guillaume²,Negri Steven²,Cogulet Virginie⁵,Huon Jean-François⁶^ORCID,Grégoire Matthieu⁷^ORCID,Papon Nicolas²^ORCID,Le Pape Patrice³⁴,Bouchara Jean-Philippe²,Nevez Gilles¹²^ORCID

Affiliation:

1. Laboratoire de Parasitologie et Mycologie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France

2. Université d’Angers, Université de Brest, Groupe d’Étude des Interactions Hôte-Pathogène (GEIHP), France

3. Laboratoire de Parasitologie et Mycologie, CHU de Nantes, Nantes, France

4. Cibles et Médicaments des Infections et du Cancer, IICiMed UPRES EA 1155, UFR de Sciences Pharmaceutiques et Biologiques, Nantes, France

5. Pharmacie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France

6. Clinical Pharmacy Unit, CHU de Nantes, Nantes, France

7. Clinical Pharmacology Department, CHU Nantes and EE1701, Microbiotas Hosts Antibiotics and Bacterial Resistances, Nantes University, Nantes, France

Abstract

Echinocandins are noncompetitive inhibitors of the GSC1 subunit of the enzymatic complex involved in synthesis of 1,3-beta- d -glucan, a cell wall component of most fungi, including Pneumocystis spp. Echinocandins are widely used for treating systemic candidiasis and rarely used for treating Pneumocystis pneumonia.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01563-21

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