Affiliation:
1. School of Veterinary Medicine and Biomedical Sciences, University of Nebraska—Lincoln, and Nebraska Center for Virology, University of Nebraska—Lincoln, Lincoln, Nebraska, USA
Abstract
ABSTRACT
Alphaherpesvirinae
family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter more than 150-fold. Conversely, other viral promoters (VP16 and ICP4) were not strongly stimulated, suggesting that the ICP0 promoter is preferentially activated by dexamethasone-simulated stress.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
17 articles.
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