Anucleate Cell Blue Assay: a Useful Tool for Identifying Novel Type II Topoisomerase Inhibitors-Reference-Cited by-同舟云学术

Anucleate Cell Blue Assay: a Useful Tool for Identifying Novel Type II Topoisomerase Inhibitors

Published:2006-01 Issue:1 Volume:50 Page:348-350
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Oyamada Yoshihiro¹,Ito Hideaki¹,Fujimoto-Nakamura Mika¹,Tanitame Akihiko²,Iwai Noritaka³,Nagai Kazuo⁴,Yamagishi Jun-ichi¹,Wachi Masaaki³

Affiliation:

1. Pharmacology & Microbiology Research Laboratories

2. Chemical Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki 33-94, Suita, Osaka 564-0053

3. Department of Bioengineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501

4. Department of Biological Chemistry, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan

Abstract

ABSTRACT About 95,000 compounds were screened by the anucleate cell blue assay. Fifty-one of the hit compounds had various structures and showed inhibitory activity against DNA gyrase and/or topoisomerase IV. Moreover, the compounds exhibited antibacterial activity against a fluoroquinolone- and novobiocin-resistant strain of Staphylococcu s aureus . The anucleate cell blue assay is therefore a useful tool for finding novel type II topoisomerase inhibitors.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.1.348-350.2006

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