Affiliation:
1. Public Health Research Institute, 225 Warren St., Newark, New Jersey 07103
Abstract
ABSTRACT
Inhibition of DNA replication in an
Escherichia coli dnaB-22
mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both
dnaB-22
and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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