Molecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus

Author:

Huang Li12,Matsuo Miki1,Calderón Carlos3,Fan Sook-Ha1,Ammanath Aparna Viswanathan1,Fu Xiaoqing3,Li Ningna1,Luqman Arif1,Ullrich Marvin4,Herrmann Florian4,Maier Martin4,Cheng Anchun2ORCID,Zhang Fajun5,Oesterhelt Filipp6,Lämmerhofer Michael3,Götz Friedrich17ORCID

Affiliation:

1. Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, Germany

2. Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

3. Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany

4. Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany

5. Institute of Applied Physics, University of Tübingen, Tübingen, Germany

6. Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Tübingen, Germany

7. Excellence Cluster 2124 ‘Controlling Microbes to Fight Infections’ (CMFI), University of Tübingen, Tübingen, Germany

Abstract

Antibiotic resistance is a growing public health problem, and alternative antibiotics are urgently needed. Rhodomyrtone (Rom), an antimicrobial compound originally isolated from Rhodomyrtus tomentosa , is active against multiple resistant Gram-positive pathogens.

Funder

Chinese Government Scholarship

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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