Transition of Dephospho-DctD to the Transcriptionally Active State via Interaction with Dephospho-IIA Glc

Abstract

Transcription regulation by bacterial two-component systems is achieved by a response regulator upon its transition to the transcriptionally active form via kinase activity of its cognate sensor under specific conditions. A well-known response regulator, DctD, is converted to its phosphorylated form when DctB senses ambient dicarboxylic acids.