Mycobacterium tuberculosis Transcription Factor EmbR Regulates the Expression of Key Virulence Factors That Aid in <i>Ex Vivo</i> and <i>In Vivo</i> Survival-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis Transcription Factor EmbR Regulates the Expression of Key Virulence Factors That Aid in Ex Vivo and In Vivo Survival

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kumar Suresh¹,Khan Mehak Zahoor¹,Khandelwal Neha²,Chongtham Chen¹,Singha Biplab¹,Dabla Ankita¹,Behera Debashree³,Singh Archana⁴,Gopal Balasubramanian³^ORCID,Arimbasseri G. Aneeshkumar¹,Kamat Siddhesh S.²,Nandicoori Vinay Kumar¹^ORCID

Affiliation:

1. National Institute of Immunology, New Delhi, India

2. Department of Biology, Indian Institute of Science Education and Research, Pune, India

3. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

4. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

Abstract

Mycobacterium tuberculosis modulates its transcriptional machinery in response to dynamic microenvironments encountered within the host. In this study, we identified that EmbR, a transcription factor, plays important roles in modulating cellular morphology, antibiotic resistance, and survival in the host.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Science and Engineering Research Board

DST | Science and Engineering Research Board

The Wellcome Trust DBT India Alliance

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03836-21