Characterization of an Anticryptococcal Protein Isolated from Human Serum-Reference-Cited by-同舟云学术

Characterization of an Anticryptococcal Protein Isolated from Human Serum

Published:2000-06 Issue:6 Volume:68 Page:3787-3791
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sridhar Sridevi¹,Ahluwalia Mala¹,Brummer Elmer¹²,Stevens David A.¹²

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose,1 and

2. Stanford University School of Medicine, Stanford,2 California

Abstract

ABSTRACT Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of ∼81.8 kDa, a pI of ∼6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity and that of apotransferrin and 5% human serum were reversed by 10 μM freshly prepared FeCl 3 .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.6.3787-3791.2000

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3. Human defenses against Cryptococcus neoformans: an update;Brummer E.;Mycopathologia,1999

4. The coincidence of cryptococcosis and disease of the reticuloendothelial system;Collins V. P.;Cancer,1951

5. Isolation of a human serum protein that inhibits the growth of Cryptococcus neoformans;Duvvuru S.;Mycopathologia,1999

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