Prevalence of bla CTX-M Genes in Gram-Negative Bloodstream Isolates across 66 Hospitals in the United States

Author:

Tamma Pranita D.1ORCID,Smith Tiffeny T.2,Adebayo Ayomikun3,Karaba Sara M.4,Jacobs Emily3,Wakefield Teresa3,Nguyen Kelly2,Whitfield Natalie N.2ORCID,Simner Patricia J.3ORCID

Affiliation:

1. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. GenMark Diagnostics Inc., Carlsbad, California, USA

3. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

4. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

Understanding bacterial species at highest risk for harboring bla CTX-M genes is necessary to guide antibiotic treatment. We identified the species-specific prevalence of bla CTX-M genes in clinical isolates from the United States.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference22 articles.

1. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States 2019. www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. Accessed December 12th 2020.

2. The Center for Disease Dynamics Economics & Policy. Resistance Map. https://resistancemap.cddep.org/AntibioticResistance.php. Accessed December 12th 2020.

3. Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017

4. Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype

5. Epidemiology and Risk Factors for Isolation of Escherichia coli Producing CTX-M-Type Extended-Spectrum β-Lactamase in a Large U.S. Medical Center

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