Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)-Reference-Cited by-同舟云学术

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

Published:2012-07-15 Issue:14 Volume:194 Page:3756-3757
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Barreiro Carlos¹,Prieto Carlos¹,Sola-Landa Alberto¹,Solera Elena¹,Martínez-Castro Miriam²,Pérez-Redondo Rosario¹,García-Estrada Carlos¹,Aparicio Jesús F.¹²,Fernández-Martínez Lorena T.¹,Santos-Aberturas Javier²,Salehi-Najafabadi Zahra²,Rodríguez-García Antonio¹²,Tauch Andreas³,Martín Juan F.²

Affiliation:

1. INBIOTEC (Instituto de Biotecnología de León), Parque Científico de León, León, Spain

2. Área de Microbiología, Departamento de Biología Molecular, Universidad de León, Campus de Vegazana, León, Spain

3. Institute for Genome Research and Systems Biology, Center for Biotechnology, Bielefeld University, Bielefeld, Germany

Abstract

ABSTRACT The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00692-12

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