Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins-Reference-Cited by-同舟云学术

Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

Published:1988-05 Issue:5 Volume:62 Page:1814-1818
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Figge J¹,Webster T¹,Smith T F¹,Paucha E¹

Affiliation:

1. Division of Neoplastic Disease Mechanisms, Dana-Farber Cancer Institute, Boston, Massachusetts.

Abstract

Regions containing similar elements of primary and predicted secondary structure were identified in simian virus 40 large T, adenovirus E1A, c-myc and v-myc proteins by a computer program with a set of highly specific, complex pattern descriptors. In all cases these regions were localized in domains of the respective proteins known to be required for transforming activity. We suggest that these apparently structurally similar regions may mediate a common biological function.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.62.5.1814-1818.1988

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