Molecular Characterization of the β-Lactamases from Clinical Isolates of Moraxella ( Branhamella ) catarrhalis Obtained from 24 U.S. Medical Centers during 1994–1995 and 1997

Molecular Characterization of the β-Lactamases from Clinical Isolates of Moraxella ( Branhamella ) catarrhalis Obtained from 24 U.S. Medical Centers during 1994–1995 and 1997–1998

Published:2000-02 Issue:2 Volume:44 Page:444-446
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Richter Sandra S.¹,Winokur Patricia L.¹,Brueggemann Angela B.¹,Huynh Holly K.¹,Rhomberg Paul R.¹,Wingert Elizabeth M.¹,Doern Gary V.¹

Affiliation:

1. Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa

Abstract

ABSTRACT The β-lactamases from 403 Moraxella ( Branhamella ) catarrhalis clinical isolates obtained during 1994–1995 and 1997–1998 U.S. multicenter surveillance studies were characterized by isoelectric focusing. The overall prevalences of the BRO-1 and BRO-2 enzymes among β-lactamase-positive isolates were estimated to be 97.5 and 2.5%, respectively. The minimum inhibitory concentrations (MICs) of ampicillin for all BRO-2-producing isolates were ≤1 μg/ml; however, numerous β-lactamase-positive isolates for which the ampicillin MICs were ≤1 μg/ml produced the BRO-1 enzyme (88.1%).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.2.444-446.2000

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