Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages-Reference-Cited by-同舟云学术

Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages

Published:2000-02 Issue:2 Volume:44 Page:405-407
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Clayette Pascal¹²,Martin Marc¹,Beringue Vincent¹,Dereuddre-Bosquet Nathalie¹²,Adjou Karim T.¹³,Seman Michel⁴,Dormont Dominique¹

Affiliation:

1. CEA, Service de Neurovirologie, DSV/DRM, CRSSA, IPSC, Fontenay aux Roses,1

2. SPI-BIO, Massy,2

3. Laboratoires Mayoly-Spindler, Chatou,3 France

4. Laboratoire d'Immunodifférenciation, Université Denis Diderot, Paris,4 and

Abstract

ABSTRACT Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-α) mRNA expression and TNF-α production and consequently HIV replication in human macrophages. These effects confirm the pharmacological risk associated with the administration of amphotericin B or its derivatives to HIV-infected patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.2.405-407.2000

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