Affiliation:
1. Centre de Recherche en Infectiologie, Centre Hospitalier de l’Université Laval, and Département de Microbiologie, Faculté de Médecine, UniversitéLaval, Québec, Canada G1V 4G2
Abstract
ABSTRACT
We investigated the influence of HMR 3004, a new ketolide antibiotic, on the pulmonary inflammation induced by heat-killed fluorescein isothiocyanate-labeled
Streptococcus pneumoniae
. HMR 3004 downregulated (
P
< 0.05) the pneumococcus-induced release of interleukin-6 (IL-6), IL-1β, and nitric oxide in bronchoalveolar lavage fluid. The drug limited (
P
< 0.05) neutrophil recruitment to lung tissues and alveoli but did not interfere with phagocytosis. HMR 3004 totally abrogated lung edema. By reducing inflammation in addition to possessing antimicrobial properties, HMR 3004 may participate in improving the outcome of bacterial pneumonia.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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