Affiliation:
1. Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
Abstract
ABSTRACT
We tested 16 erythromycin-resistant clinical isolates of
S. aureus
, recovered from patients hospitalized in the United States from 1958 to 1969, for the presence of
ermA
,
ermB
, and
ermC
by using PCR. Fifteen of 16 isolates contained at least one copy of
ermA
; the remaining isolate, which was also clindamycin resistant, contained
ermB
. Eight of the 15 isolates harboring
ermA
, all of which were inducible, contained a single copy of the gene in the chromosome, while the remaining seven isolates had two copies of the gene.
ermB
was plasmid encoded and mediated constitutive resistance to erythromycin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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