Treatment of Histoplasmosis with MK-991 (L-743,872)-Reference-Cited by-同舟云学术

Treatment of Histoplasmosis with MK-991 (L-743,872)

Published:1998-01 Issue:1 Volume:42 Page:151-153
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Graybill John R.¹²,Najvar Laura K.¹,Montalbo Eleanor M.¹,Barchiesi Francesco J.¹,Luther Michael F.²,Rinaldi Michael G.¹²

Affiliation:

1. The University of Texas Health Science Center at San Antonio,1 and

2. South Texas Veterans Health Care System, Audie Murphy Division,2 San Antonio, Texas 78284

Abstract

ABSTRACT BALB/c nu /+ immunocompetent and athymic ( nu/nu ) mice were infected intravenously with yeast cells of Histoplasma capsulatum . Mice were either given water (controls) intraperitoneally (i.p.) or given MK-991 i.p. once daily or twice daily. Protection was measured as prolonged survival or reduction in tissue counts. MK-991 was protective in immunocompetent mice, prolonging survival and reducing counts in spleen and livers at a dose as low as 0.05 mg/kg of body weight/day. MK-991 was modestly effective in athymic mice at a higher dose, 5 mg/kg/day. These studies suggest that MK-991 may be appropriate for clinical development in histoplasmosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.1.151

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