Serum-Based Diagnosis of Pediatric Tuberculosis by Assay of Mycobacterium tuberculosis Factors: a Retrospective Cohort Study-Reference-Cited by-同舟云学术

Serum-Based Diagnosis of Pediatric Tuberculosis by Assay of Mycobacterium tuberculosis Factors: a Retrospective Cohort Study

Published:2021-01-21 Issue:2 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

He Yifan¹²,Lyon Christopher J.¹,Nguyen Duc T.³,Liu Chang⁴,Sha Wei¹,Graviss Edward A.³,Hu Tony Y.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology Center for Cellular and Molecular Diagnosis, School of Medicine, Tulane University, New Orleans, Louisiana, USA

2. Shanghai Clinical Research Center for Infectious Diseases (Tuberculosis), Shanghai, China

3. Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA

4. Department of Chemical Engineering, Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, USA

Abstract

Diagnosis of pediatric tuberculosis (TB) is often complicated by its nonspecific symptoms, paucibacillary nature, and the need for invasive specimen collection techniques. However, a recently reported assay that detects Mycobacterium tuberculosis virulence factors in serum can diagnose various TB manifestations, including paucibacillary TB cases, in adults with good sensitivity and specificity.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Defense

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01756-20

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