Isolation and Characterization of an Isolate (HN) of Marek's Disease Virus with Low Pathogenicity-Reference-Cited by-同舟云学术

Isolation and Characterization of an Isolate (HN) of Marek's Disease Virus with Low Pathogenicity

Published:1972-09 Issue:3 Volume:24 Page:299-306
ISSN:0003-6919
Container-title:Applied Microbiology
language:en
Short-container-title:Appl Microbiol

Author:

Cho B. R.¹²,Kenzy S. G.¹²

Affiliation:

1. Department of Veterinary Science, Agricultural Experiment Station, Washington State University, Pullman, Washington 99163

2. Department of Veterinary Microbiology, Washington State University, Pullman, Washington 99163

Abstract

A cytopathic agent was isolated and characterized as an isolate of Marek's disease herpesvirus (MDHV) with low pathogenicity, and referred to as the HN isolate. This isolate of MDHV did not cause clinical Marek's disease (MD) or death in a highly susceptible line of chickens within 5 weeks after exposure. Gross lesions of limited extent were noted in a few of the inoculated birds. Microscopic nerve lesions in the inoculated and contact-infected birds were invariably minimal, closely resembling C-type MD lesions.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://journals.asm.org/doi/pdf/10.1128/am.24.3.299-306.1972

Reference26 articles.

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3. Biggs P. M. and B. S. Milne. 1971. Biological proper- ties of a number of Marek's disease virus isolates p. 12. In P. M. Biggs G. de-The and L. N. Payne (ed.) Oncogenesis and herpesviruses. IARC Lyon France.

4. Studies on Marek's disease. I. Experimental transmission;Biggs P. M.;J. Nat. Cancer Inst.,1967

5. Preliminary report on acute Marek's disease (fowl paralysis) in Great;Biggs P. M.;Britain. Vet. Rec.,1965

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