Therapeutic Effects of Water-Soluble Echinocandin Compounds on Pneumocystis Pneumonia in Mice

Author:

Furuta Takahisa1,Muramatsu Hideyuki2,Fujie Akihiko2,Fujihira Shiro3,Rain Abudullah Noor4,Kojima Somei1

Affiliation:

1. Department of Parasitology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108,1

2. Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba-shi, Ibaraki, 300-26,2 and

3. Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka-shi, Osaka, 532,3 Japan, and

4. Biotechnology Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia4

Abstract

ABSTRACT The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Fujie A. Iwamoto T. Kasahara C. Yamashita Y. Hashimoto S. Okumura M. FR131535 a novel lipopeptide antifungal Abstracts of papers of the Annual Meeting of Japan Society for Bioscience Biotechnology and Agrochemistry. (In Japanese.) 1996 51

2. Effect of T cell transfer on Pneumocystis carinii infection in nude mice;Furuta T.;Jpn. J. Exp. Med.,1984

3. Severe pulmonary pneumocystosis in simian acquired immunodeficiency syndrome induced by simian immunodeficiency virus: its characterization by polymerase chain reaction method and failure of experimental transmission to immunodeficient animals;Furuta T.;Parasitol. Res.,1993

4. WF11899A, B, and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties;Iwamoto T.;J. Antibiot.,1994

5. WF11899A, B and C, novel antifungal lipopeptides. II. Biological properties;Iwamoto T.;J. Antibiot.,1997

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