Bactericidal Activities of the Pyrrole Derivative BM212 against Multidrug-Resistant and Intramacrophagic Mycobacterium tuberculosis Strains-Reference-Cited by-同舟云学术

Bactericidal Activities of the Pyrrole Derivative BM212 against Multidrug-Resistant and Intramacrophagic Mycobacterium tuberculosis Strains

Published:1998-11 Issue:11 Volume:42 Page:3035-3037
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Deidda Delia¹,Lampis Giorgio¹,Fioravanti Rossella²,Biava Mariangela²,Porretta Giulio Cesare²,Zanetti Stefania³,Pompei Raffaello¹

Affiliation:

1. Dipartimento di Scienze Mediche, Cattedra di Microbiologia, Università di Cagliari, Cagliari,1

2. Dipartimento di Studi di Chimica TSBA Università “la Sapienza” di Roma, Rome,2 and

3. Istituto di Microbiologia, Università di Sassari, Sassari,3 Italy

Abstract

ABSTRACT The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.11.3035

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