Affiliation:
1. Animal Center for Biomedical Research, Faculty of Medicine, University of Tokyo, Japan.
Abstract
We examined live virus vaccines against measles, mumps, and rubella for the presence of pestivirus RNA or of pestiviruses by reverse transcription PCR. Pestivirus RNA was detected in two measles-mumps-rubella combined vaccines and in two monovalent vaccines against mumps and rubella. Nucleotide sequence analysis of the PCR products indicated that a modified live vaccine strain used for immunization of cattle against bovine viral diarrhea is not responsible for the contamination of the vaccines.
Publisher
American Society for Microbiology
Reference19 articles.
1. Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus;Collett M. S.;Virology,1988
2. Deng R. and K. V. Brock. 1992. Molecular cloning and nucleotide sequence of a pestivirus genome non-cytopathic bovine viral
3. Giangaspero M. G. Wellemans E. Vanopdenbosch A. Belloli and A. Verhulst. 1988. Bovine viral diarrhea. Lancet ii:110.
4. Detection of adventitious pestivirus in cell cultures by polymerase chain reaction using nested-pair primers;Harasawa R.;Tissue Cult. Res. Commun.,1993
5. Attempts to characterize bovine viral diarrhea virus isolated from cattle after immunization with a contaminated vaccine;Kreeft H. A. J. G.;Dtsch. Tierarztl. Wochenschr.,1990
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