Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections-Reference-Cited by-同舟云学术

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Published:2011-01 Issue:1 Volume:24 Page:193-209
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

Odumade Oludare A.¹,Hogquist Kristin A.¹,Balfour Henry H.¹²

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota

2. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota

Abstract

SUMMARY Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/CMR.00044-10

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