Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against Sarcoptesscabiei in the Porcine Scabies Model for Human Infestation-Reference-Cited by-同舟云学术

Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against Sarcoptesscabiei in the Porcine Scabies Model for Human Infestation

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bernigaud Charlotte¹²,Fang Fang¹³,Fischer Katja⁴,Lespine Anne⁵,Aho Ludwig S.⁶,Mullins Amanda J.⁷,Tecle Berhane⁸,Kelly Andrew⁹,Sutra Jean-François⁵,Moreau Francis¹⁰,Lilin Thomas¹⁰,Beugnet Frédéric¹¹,Botterel Françoise¹¹²,Chosidow Olivier²¹³,Guillot Jacques¹¹⁴

Affiliation:

1. Research Group Dynamyc, EA7380, Université Paris-Est Créteil, Créteil, France

2. Department of Dermatology, AP-HP, Hôpital Henri Mondor, Université Paris-Est, Créteil, France

3. Department of Parasitology, College of Animal Science and Technology, Guangxi University, Nanning, China

4. Scabies Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

5. Toxalim, Research Centre in Food Toxicology, INRA, INP-ENVT, INP-EI-Purpan, Université de Toulouse, Toulouse, France

6. Epidemiology and Infection Control Unit, University Hospital of Dijon, Dijon, France

7. Missouri Research Center, Merial, Fulton, Missouri, USA

8. Pharmacokinetics and Drug Metabolism, Boehringer Ingelheim Animal Health, North Brunswick, New Jersey, USA

9. Department of Agriculture, Fisheries and Forestry, Queensland Animal Science Precinct, University of Queensland, Gatton, Australia

10. Centre de Recherche BioMédicale, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France

11. Merial, Lyon, France

12. AP-HP, Hôpital Henri Mondor, Parasitology and Mycology, Department of Microbiology, DHU VIC, Université Paris-Est, Créteil, France

13. EA 7379, EpiDermE, Epidémiologie en Dermatologie et Evaluation des Thérapeutiques and INSERM, CIC 1430, Créteil, France

14. Department of Parasitology, Biopôle Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France

Abstract

Scabies is a major and potentially growing public health problem worldwide with an unmet need for acaricidal agents with greater efficacy and improved pharmacological properties for its treatment. The objective of the present study was to assess the efficacy and describe the pharmacokinetics profile of a novel acaricide, afoxolaner (AFX), in a relevant experimental porcine model.

Funder

Socitété française de dermatologie

Fondation René Touraibe pour la Dermatologie

China Scholarship Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02334-17

Reference43 articles.

1. Scabies