The Cationic Antimicrobial Peptide Activity of Lysozyme Reduces Viable <i>Enterococcus faecalis</i> Cells in Biofilms-Reference-Cited by-同舟云学术

The Cationic Antimicrobial Peptide Activity of Lysozyme Reduces Viable Enterococcus faecalis Cells in Biofilms

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rouchon Candace N.¹²,Harris Joann¹,Zubair-Nizami Zahra¹²,Weinstein Arielle J.¹²,Roky Mohammad¹²,Frank Kristi L.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

2. Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA

Abstract

Enterococcus faecalis , a leading cause of health care-associated infections, forms biofilms and is resistant to many antimicrobial agents. Planktonic-phase E. faecalis is resistant to high concentrations of the enzyme lysozyme, which catalyzes the hydrolysis of N -acetylmuramic acid and N -acetylglucosamine linkages in peptidoglycan and is also a cationic antimicrobial peptide (CAMP). E. faecalis lysozyme resistance in planktonic cells is stimulated upon activation of the extracytoplasmic function sigma factor SigV via cleavage of the anti-sigma factor RsiV by the transmembrane protease Eep.

Funder

DOD | Uniformed Services University of the Health Sciences

American Heart Association

U.S. Department of Defense

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02339-21

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