Evolution of Enterococcus faecium in Response to a Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies-Reference-Cited by-同舟云学术

Evolution of Enterococcus faecium in Response to a Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies

Published:2022-06-21 Issue:6 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Supandy Adeline¹,Mehta Heer H.¹,Tran Truc T.²^ORCID,Miller William R.²³^ORCID,Zhang Rutan⁴,Xu Libin⁴^ORCID,Arias Cesar A.²³,Shamoo Yousif¹^ORCID

Affiliation:

1. Department of Biosciences, Rice University, Houston, Texas, USA

2. Center for Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA

3. Division of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA

4. Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA

Abstract

Infections caused by vancomycin-resistant Enterococcus faecium (VREfm) are an important public health threat. VREfm isolates have become increasingly resistant to the front-line antibiotic daptomycin (DAP). As such, the use of DAP combination therapies with other antibiotics like fosfomycin (FOS) has received increased attention.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02333-21

Reference60 articles.

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