Mutational Analysis of Metronidazole Resistance in Helicobacter pylori-Reference-Cited by-同舟云学术

Mutational Analysis of Metronidazole Resistance in Helicobacter pylori

Published:2005-03 Issue:3 Volume:49 Page:1236-1237
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Moore Jill M.¹,Salama Nina R.¹

Affiliation:

1. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington

Abstract

ABSTRACT Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.3.1236-1237.2005

Reference14 articles.

1. Alarcon, T., D. Domingo, and M. Lopez-Brea. 1999. Antibiotic resistance problems with Helicobacter pylori.Int. J. Antimicrob. Agents12:19-26.

2. Biery, M. C., F. J. Stewart, A. E. Stellwagen, E. A. Raleigh, and N. L. Craig. 2000. A simple in vitro Tn7-based transposition system with low target site selectivity for genome and gene analysis. Nucleic Acids Res.28:1067-1077.

3. Chisholm, S. A., and R. J. Owen. 2004. Frameshift mutations in frxA occur frequently and do not provide a reliable marker for metronidazole resistance in UK isolates of Helicobacter pylori.J. Med. Microbiol.53:135-140.

4. Covacci, A., S. Censini, M. Bugnoli, R. Petracca, D. Burroni, G. Macchia, A. Massone, E. Papini, Z. Xiang, N. Figura, and R. Rappuoli. 1993. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. USA90:5791-5795.

5. Helicobacter pylori Virulence and Genetic Geography

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