Evaluation of Ceftobiprole in a Rabbit Model of Aortic Valve Endocarditis Due to Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus-Reference-Cited by-同舟云学术

Evaluation of Ceftobiprole in a Rabbit Model of Aortic Valve Endocarditis Due to Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus

Published:2005-03 Issue:3 Volume:49 Page:884-888
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chambers Henry F.¹

Affiliation:

1. Division of Infectious Diseases, San Francisco General Hospital, and University of California—San Francisco, San Francisco, California

Abstract

ABSTRACT Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the methicillin-resistance determinant of staphylococci, and is active against methicillin- and vancomycin-resistant Staphylococcus aureus . Ceftobiprole was compared to vancomycin in a rabbit model of methicillin-resistant S . aureus aortic valve endocarditis. Ceftobiprole and vancomycin were equally effective against endocarditis caused by methicillin-resistant S . aureus strain 76, whereas ceftobiprole was more effective than vancomycin against the vancomycin-intermediate S . aureus strain HIP5836. The activity of ceftobiprole against drug-resistant strains of S . aureus warrants its further clinical development.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.3.884-888.2005

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