Activity of Cathelicidin Peptides against Chlamydia spp

Author:

Donati Manuela1,Di Leo Korinne1,Benincasa Monica2,Cavrini Francesca1,Accardo Silvia1,Moroni Alessandra1,Gennaro Renato2,Cevenini Roberto1

Affiliation:

1. Sezione di Microbiologia, DMCSS, Policlinico S. Orsola, University of Bologna, Bologna

2. Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Trieste, Italy

Abstract

ABSTRACT The in vitro activity of six cathelicidin peptides against 25 strains of Chlamydia was investigated. SMAP-29 proved to be the most active peptide, reducing the inclusion numbers of all 10 strains of Chlamydia trachomatis tested by ≥50% at 10 μg/ml. This peptide was also active against C. pneumoniae and C. felis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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