Preferential Binding of Mouse Mammary Tumor Virus to B Lymphocytes-Reference-Cited by-同舟云学术

Preferential Binding of Mouse Mammary Tumor Virus to B Lymphocytes

Published:1999-09 Issue:9 Volume:73 Page:7899-7902
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Baribaud Frédéric¹,Vessaz Shaw Annelyse¹,Scarpellino Leo²³,Diggelmann Heidi¹,Acha-Orbea Hans²³

Affiliation:

1. Institute of Microbiology, University of Lausanne, CH-1011 Lausanne,1 and

2. Institute of Biochemistry, University of Lausanne,2 and

3. Ludwig Institute for Cancer Research, Lausanne Branch,3 CH-1066 Epalinges, Switzerland

Abstract

ABSTRACT Mouse mammary tumor virus (MMTV) has been shown to preferentially infect B lymphocytes in vivo. We have used recombinant envelope-coated fluospheres and highly purified MMTV particles to study the distribution of the viral receptors on fresh mouse lymphocytes. A preferential dose-dependent binding to B lymphocytes was observed which could be competed with neutralizing antibodies. In contrast, T-lymphocyte binding remained at background levels. These results strongly suggest a higher density of viral receptor molecules on B lymphocytes than on T lymphocytes and correlate with the preferential initial infection of B lymphocytes observed in vivo.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.9.7899-7902.1999

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