Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models-Reference-Cited by-同舟云学术

Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models

Published:2019-03-15 Issue:6 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Soulez Mathilde¹,Saba-El-Leil Marc K.¹,Turgeon Benjamin¹²,Mathien Simon¹²,Coulombe Philippe¹²,Klinger Sonia¹,Rousseau Justine¹,Lévesque Kim¹,Meloche Sylvain¹²³

Affiliation:

1. Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada

2. Program of Molecular Biology, Université de Montréal, Montreal, Quebec, Canada

3. Department of Pharmacology and Physiology, Université de Montréal, Montreal, Quebec, Canada

Abstract

The physiological functions of the atypical mitogen-activated protein kinase extracellular signal-regulated kinase 3 (ERK3) remain poorly characterized. Previous analysis of mice with a targeted insertion of the lacZ reporter in the Mapk6 locus ( Mapk6 lacZ ) showed that inactivation of ERK3 in Mapk6 lacZ mice leads to perinatal lethality associated with intrauterine growth restriction, defective lung maturation, and neuromuscular anomalies.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00527-18

Reference22 articles.

1. Mathien S, Soulez M, Klinger S, Meloche S. 2018. Erk3 and Erk4, p 1632–1638. In Choi S (ed), Encyclopedia of signaling molecules, 2nd ed. Springer International Publishing, Cham, Switzerland.

2. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF;Boulton TG;Cell,1991

3. Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa