RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons-Reference-Cited by-同舟云学术

RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons

Published:2021-06-23 Issue:7 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Xiang Chaomei¹,Frietze Karla K.¹,Bi Yingtao²,Li Yanwen¹,Dal Pozzo Valentina¹,Pal Sharmistha³,Alexander Noah⁴,Baubet Valerie⁵,D’Acunto Victoria¹,Mason Christopher E.⁴,Davuluri Ramana V.²,Dahmane Nadia¹⁶^ORCID

Affiliation:

1. Weill Cornell Medical College, Department of Neurological Surgery, New York, New York, USA

2. Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, Illinois, USA

3. Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

4. Weill Cornell Medical College, Department of Physiology and Biophysics, New York, New York, USA

5. Children's Hospital of Philadelphia, Center for Data Driven Discovery in Biomedicine (D3b), Philadelphia, Pennsylvania, USA

6. University of Pennsylvania School of Medicine, Department of Neurosurgery, Philadelphia, Pennsylvania, USA

Abstract

How mammalian neuronal identity is progressively acquired and reinforced during development is not understood. We have previously shown that loss of RP58 (ZNF238 or ZBTB18), a BTB/POZ- and zinc finger-containing transcription factor, in the mouse brain leads to microcephaly, corpus callosum agenesis, and cerebellum hypoplasia and that it is required for normal neuronal differentiation.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00526-20

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