Molluscum Contagiosum Virus Protein MC008 Targets NF-κB Activation by Inhibiting Ubiquitination of NEMO-Reference-Cited by-同舟云学术

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Molluscum Contagiosum Virus Protein MC008 Targets NF-κB Activation by Inhibiting Ubiquitination of NEMO

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Phelan Thomas¹,Lawler Clara¹,Pichlmair Andreas²,Little Mark A.¹,Bowie Andrew G.³,Brady Gareth¹^ORCID

Affiliation:

1. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, St. James’ Hospital Campus, Dublin, Ireland

2. Max Plank Institute of Biochemistry, Martinsried, Germany

3. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

Abstract

Inflammation lies at the heart of most human diseases. Understanding the pathways that drive this response is the key to new anti-inflammatory therapies.

Funder

Science Foundation Ireland

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00108-23

Reference59 articles.

1. Viral evasion of DNA-stimulated innate immune responses

2. Innate immune detection of microbial nucleic acids

3. Ubiquitin-mediated activation of TAK1 and IKK

4. The IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface

5. Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

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