Adeno-Associated Virus Receptor-Binding: Flexible Domains and Alternative Conformations through Cryo-Electron Tomography of Adeno-Associated Virus 2 (AAV2) and AAV5 Complexes-Reference-Cited by-同舟云学术

Adeno-Associated Virus Receptor-Binding: Flexible Domains and Alternative Conformations through Cryo-Electron Tomography of Adeno-Associated Virus 2 (AAV2) and AAV5 Complexes

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hu Guiqing¹,Silveria Mark A.²,Zane Grant M.²,Chapman Michael S.²^ORCID,Stagg Scott M.¹³^ORCID

Affiliation:

1. Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA

2. Department of Biochemistry, University of Missouri, Columbia, Missouri, USA

3. Department of Biological Sciences, Florida State University, Tallahassee, Florida, USA

Abstract

With 150 clinical trials for 30 diseases under way, AAV is a leading gene therapy vector. Immunotoxicity at high doses used to overcome inefficient transduction has occasionally proven fatal and highlighted gaps in fundamental virology.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00106-22

Reference87 articles.

1. The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy

2. Physical Principles in the Construction of Regular Viruses

3. Adenovirus-Associated Defective Virus Particles