Type I Interferon Orchestrates Demand-Adapted Monopoiesis during Influenza A Virus Infection via STAT1-Mediated Upregulation of Macrophage Colony-Stimulating Factor Receptor Expression-Reference-Cited by-同舟云学术

Type I Interferon Orchestrates Demand-Adapted Monopoiesis during Influenza A Virus Infection via STAT1-Mediated Upregulation of Macrophage Colony-Stimulating Factor Receptor Expression

Published:2023-04-27 Issue:4 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lin Sue-Jane¹,Lin Kai-Min¹,Chen Shi-Yo Jill¹,Ku Chia-Chi²,Huang Chen-Wei³,Huang Chi-Hsiang⁴,Gale Michael⁵,Tsai Ching-Hwa¹^ORCID

Affiliation:

1. Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

2. Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan

3. Department of Family Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

4. Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

5. Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, USA

Abstract

Our findings show that influenza A virus infection induces type I interferon (IFN)-mediated emergency hematopoiesis to expand the GMP population in the bone marrow. The type I IFN-STAT1 axis was identified as being involved in mediating the viral-infection-driven demand-adapted monopoiesis by upregulating M-CSFR expression in the GMP population.

Funder

National Health Research Institutes

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00102-23

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