Preferential Inhibition of Penicillinase Induction by Oxytetracycline and Its Effect on the Penicillin Susceptibility of Staphylococci-Reference-Cited by-同舟云学术

Preferential Inhibition of Penicillinase Induction by Oxytetracycline and Its Effect on the Penicillin Susceptibility of Staphylococci

Published:1967-06 Issue:6 Volume:93 Page:1749-1752
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Michael Thomas M.¹,Michael J. Gabriel¹,Massell Benedict F.¹

Affiliation:

1. House of the Good Samaritan, Children's Hospital Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Exposure of penicillinase-producing staphylococci to a combination of penicillin and oxytetracycline resulted in a synergistic inhibitory activity of the antibiotics on the bacteria. Oxytetracycline was employed in concentrations having little or no effect on bacterial growth. It was found that the synergistic antibacterial effect was caused by the preferential inhibition of penicillinase induction by oxytetracycline, rendering the staphylococci more susceptible to penicillin.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.93.6.1749-1752.1967

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2. Prophylaxis of streptococcal infections and rheumatic fever: a comparison of orally administered clindamycin and penicillin;JAMA: The Journal of the American Medical Association;1979-04-13

3. Mechanism of Penicillin-Erythromycin Synergy on Antibiotic-ResistantStaphylococcus aureus;Antimicrobial Agents and Chemotherapy;1978-05

4. INDUCTION OF PENICILLIN SUSCEPTIBILITY IN HOSPITAL STRAINS OF PENICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS : A NEW THERAPEUTIC PATHWAY;Medical Journal of Australia;1969-03