A New Long Noncoding RNA, MAHAT, Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting DDX6 To Bind to <i>ZNF34</i> and Promote an Innate Immune Response-Reference-Cited by-同舟云学术

A New Long Noncoding RNA, MAHAT, Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting DDX6 To Bind to ZNF34 and Promote an Innate Immune Response

Published:2022-09-28 Issue:18 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Liu Yuming¹,Liu Xing¹,Bai Juan¹,Sun Yangyang¹,Nauwynck Hans²,Wang Xianwei¹,Yang Yuanqi¹,Jiang Ping¹³^ORCID

Affiliation:

1. Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

2. Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China

Abstract

Long noncoding RNAs (lncRNAs) play important roles in viral infection by regulating the transcription and expression of host genes, and interferon signaling pathways. Porcine reproductive and respiratory syndrome virus (PRRSV) causes huge economic losses in the swine industry worldwide, but the mechanisms of its pathogenesis and immunology are not fully understood.

Funder

National Natural Science Foundation of China

MOA | Earmarked Fund for China Agriculture Research System

Priority Academic Program Development of Jiangsu Higher Education Institutions

Jiangsu Independent Innovation Fund Project

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01154-22

Reference84 articles.