Unique Evolution of Antiviral Tetherin in Bats

Author:

Hayward Joshua A.12ORCID,Tachedjian Mary3,Johnson Adam1,Irving Aaron T.456,Gordon Tamsin B.12,Cui Jie7,Nicolas Alexis3,Smith Ina8,Boyd Victoria3,Marsh Glenn A.3,Baker Michelle L.3,Wang Lin-Fa6910ORCID,Tachedjian Gilda1210ORCID

Affiliation:

1. Health Security Program, Life Sciences Discipline, Burnet Institute, Melbourne, Victoria, Australia

2. Department of Microbiology, Monash University, Clayton, Victoria, Australia

3. CSIRO, Australian Centre for Disease Preparedness, Health and Biosecurity Business Unit, Geelong, Victoria, Australia

4. Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University International Campus, Haining, Zhejiang, China

5. Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

6. Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore

7. CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Beijing, China

8. CSIRO, Health and Biosecurity Business Unit, Acton, Australian Capital Territory, Australia

9. Singhealth Duke-NUS Global Health Institute, Singapore, Singapore

10. Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

Abstract

Bats are an important host of various viruses which are deadly to humans and other mammals but do not cause outward signs of illness in bats. Furthering our understanding of the unique features of the immune system of bats will shed light on how they tolerate viral infections, potentially informing novel antiviral strategies in humans and other animals.

Funder

Department of Health | National Health and Medical Research Council

National Research Foundation Singapore

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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