Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice-Reference-Cited by-同舟云学术

Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice

Published:2022-03-23 Issue:6 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sharon Andrew J.¹^ORCID,Filyk Heather A.¹,Fonseca Nicolette M.¹^ORCID,Simister Rachel L.¹,Filler Renata B.²^ORCID,Yuen Wallace¹,Hardman Blair K.¹,Robinson Hannah G.¹,Seo Jung Hee¹,Rocha-Pereira Joana³,Welch Ian⁴,Neyts Johan³,Wilen Craig B.²⁵^ORCID,Crowe Sean A.¹^ORCID,Osborne Lisa C.¹^ORCID

Affiliation:

1. Department of Microbiology & Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada

2. Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA

3. Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven–University of Leuven, Leuven, Belgium

4. Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada

5. Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA

Abstract

The intestinal microbiota is a collection of bacteria, archaea, fungi, and viruses that colonize the mammalian gut. Coevolution of the host and microbiota has required development of immunological tolerance to prevent ongoing inflammatory responses against intestinal microbes.

Funder

Canada Research Chairs

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02065-21

Reference57 articles.

1. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism

2. Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

3. NFIL3-Deficient Mice Develop Microbiota-Dependent, IL-12/23–Driven Spontaneous Colitis

4. Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

5. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

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