Effect of Difference in Consensus Sequence between HIV-1 Subtype A/E and Subtype B Viruses on Elicitation of Gag-Specific CD8 + T Cells and Accumulation of HLA-Associated Escape Mutations-Reference-Cited by-同舟云学术

Effect of Difference in Consensus Sequence between HIV-1 Subtype A/E and Subtype B Viruses on Elicitation of Gag-Specific CD8 + T Cells and Accumulation of HLA-Associated Escape Mutations

Published:2021-02-24 Issue:6 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhang Yu¹,Murakoshi Hayato¹,Chikata Takayuki¹,Akahoshi Tomohiro²,Tran Giang Van³⁴,Nguyen Trung Vu³⁴,Gatanaga Hiroyuki¹⁵,Nguyen Kinh Van³,Oka Shinichi¹⁵,Kuse Nozomi¹,Takiguchi Masafumi¹^ORCID

Affiliation:

1. Tokyo Joint Laboratory and Division of International Collaboration Research, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Tokyo, Japan

2. Center for AIDS Research, Kumamoto University, Kumamoto, Japan

3. National Hospital of Tropical Diseases, Hanoi, Vietnam

4. Hanoi Medical University, Hanoi, Vietnam

5. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan

Abstract

HIV-1 mutations escaped from HIV-specific CD8 + T cells are mostly detected as HLA-associated mutations. A diversity of HLA-associated mutations is somewhat distinct to each race and region, since HLA allele distribution differs among them.

Funder

Nagasaki University

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02061-20

Reference52 articles.

1. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition