A rot Mutation Restores Parental Virulence to an agr -Null Staphylococcus aureus Strain in a Rabbit Model of Endocarditis-Reference-Cited by-同舟云学术

A rot Mutation Restores Parental Virulence to an agr -Null Staphylococcus aureus Strain in a Rabbit Model of Endocarditis

Published:2005-06 Issue:6 Volume:73 Page:3806-3809
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McNamara Peter J.¹,Bayer Arnold S.²³

Affiliation:

1. Department of Medical Microbiology & Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706

2. LA Biomedical Research Institute at Harbor-UCLA, Torrance, California 90502

3. Geffen School of Medicine at UCLA, Los Angeles, California 90024

Abstract

ABSTRACT Mutations in rot restore in vitro toxin production to agr -negative strains of Staphylococcus aureus . We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.6.3806-3809.2005

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