Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology-Reference-Cited by-同舟云学术

Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology

Published:2015-10 Issue:10 Volume:22 Page:1130-1132
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Kingston Hugh W. F.¹²,Blacksell Stuart D.¹³,Tanganuchitcharnchai Ampai¹,Laongnualpanich Achara⁴,Basnyat Buddha⁵,Day Nicholas P. J.¹³,Paris Daniel H.¹³^ORCID

Affiliation:

1. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom

4. Chiangrai Prachanukhru Hospital, Chiangrai, Thailand

5. Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal

Abstract

ABSTRACT This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00390-15

Reference12 articles.

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2. Diagnostic Accuracy of a Loop-Mediated Isothermal PCR Assay for Detection of Orientia tsutsugamushi during Acute Scrub Typhus Infection

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4. Accuracy of AccessBio Immunoglobulin M and Total Antibody Rapid Immunochromatographic Assays for the Diagnosis of Acute Scrub Typhus Infection

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