Heterogeneous Macrolide Resistance and Gene Conversion in the Pneumococcus-Reference-Cited by-同舟云学术

Heterogeneous Macrolide Resistance and Gene Conversion in the Pneumococcus

Published:2006-01 Issue:1 Volume:50 Page:359-361
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wolter Nicole¹,Smith Anthony M.¹,Farrell David J.²,Klugman Keith P.¹³

Affiliation:

1. Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Johannesburg, South Africa

2. GR Micro Ltd., London, United Kingdom

3. Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia

Abstract

ABSTRACT A macrolide-resistant clinical isolate of Streptococcus pneumoniae with 23S rRNA mutations showed a heterogeneous phenotype and genotype. The mutant 23S rRNA genes from this isolate transformed susceptible strain R6 to resistance. Culture of resistant strain R6 in the absence of antibiotic pressure showed gene conversion to occur between the four 23S rRNA alleles, resulting in reversion to susceptibility with the resistant phenotype showing a fitness cost. These data explain the disappearance on subculture of heterogeneous macrolide resistance in the pneumococcus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.1.359-361.2006

Reference23 articles.

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