Glycosylphosphatidylinositol-Anchored Ecm33p Influences Conidial Cell Wall Biosynthesis in Aspergillus fumigatus-Reference-Cited by-同舟云学术

Glycosylphosphatidylinositol-Anchored Ecm33p Influences Conidial Cell Wall Biosynthesis in Aspergillus fumigatus

Published:2006-05 Issue:5 Volume:72 Page:3259-3267
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Chabane Sandrine¹,Sarfati Jacqueline¹,Ibrahim-Granet Oumaima¹,Du Chen²,Schmidt Christine³,Mouyna Isabelle¹,Prevost Marie-Christine³,Calderone Richard²,Latgé Jean-Paul¹

Affiliation:

1. Aspergillus Unit

2. Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D.C. 20007

3. Electron Microscopy Platform, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris Cedex 15

Abstract

ABSTRACT ECM33 encodes a glycosylphosphatidylinositol-anchored protein whose orthologs in yeast are essential for sporulation. Aspergillus fumigatus Ecm33p is unique and has an apparent mass of 55 kDa. Disruption of A. fumigatus ECM33 results in a mutant with several morphogenetic aberrations, including the following: (i) a defect in conidial separation, (ii) an increase in the diameter of the conidia of the mutant associated with an increase in the concentration of the cell wall chitin, (iii) conidia that were sensitive to the absence of aeration during long-term storage, and (iv) conidia that were more resistant to killing by phagocytes, whereas the mycelium was more easily killed by neutrophils.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.72.5.3259-3267.2006

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