Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty-Reference-Cited by-同舟云学术

Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Komatsu Toshiaki¹^ORCID,Natsume Yui²,Uchiyama Katsufumi³,Ikeda Shinsuke³,Tomoda Yoshinori⁴,Takayama Yoko⁵⁶,Takaso Masashi³,Hanaki Hideaki⁷,Atsuda Koichiro⁸

Affiliation:

1. Department of Pharmacy, Kitasato University Hospital, Kanagawa, Japan

2. Department of Pharmacy, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan

3. Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Kanagawa, Japan

4. Laboratory of Clinical Pharmacokinetics, Research and Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, Tokyo, Japan

5. Department of Infection Control and Infectious Diseases, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Kanagawa, Japan

6. Department of Infection Control and Prevention, Kitasato University Hospital, Kanagawa, Japan

7. Infection Control Research Center, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan

8. Pharmacy Practice and Science I, Research and Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, Kanagawa, Japan

Abstract

The objectives of this study were to evaluate the population pharmacokinetics of prophylactic cefazolin (CFZ) from its serum and hip joint capsule concentrations in patients undergoing total hip arthroplasty and to establish the pharmacodynamic target concentration exceeding the MIC for designing an effective dosing regimen for serum and the hip joint capsule. We analyzed 249 serum samples and 125 hip joint capsule samples from 125 individuals using a nonlinear mixed-effects model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02114-20

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