High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 + and CD4 + T Cells during Acute HCV Infection, Irrespective of Clinical Outcome-Reference-Cited by-同舟云学术

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 + and CD4 + T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

Published:2008-03-15 Issue:6 Volume:82 Page:3154-3160
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kasprowicz Victoria¹,Schulze zur Wiesch Julian¹²³,Kuntzen Thomas¹,Nolan Brian E.¹,Longworth Steven¹,Berical Andrew¹,Blum Jenna¹,McMahon Cory¹,Reyor Laura L.¹,Elias Nahel¹⁴³,Kwok William W.⁵,McGovern Barbara G.⁶,Freeman Gordon⁷,Chung Raymond T.⁸³,Klenerman Paul⁹,Lewis-Ximenez Lia¹⁰,Walker Bruce D.¹³,Allen Todd M.¹,Kim Arthur Y.¹,Lauer Georg M.¹

Affiliation:

1. Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 6th Floor, Room 6001, Charlestown, Massachusetts 02129-2000

2. Med. Klinik I, Universität Hamburg, Germany

3. Howard Hughes Medical Institute, Chevy Chase, Maryland

4. Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114

5. Benaroya Research Institute at Virginia Mason, Seattle, Washington

6. Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts

7. Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

8. Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114

9. Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom

10. Departmento de Virologia, Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil

Abstract

ABSTRACT We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8 + and CD4 + T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02474-07

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