Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones-Reference-Cited by-同舟云学术

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zuily Lisa¹,Lahrach Nora¹,Fassler Rosi²,Genest Olivier¹^ORCID,Faller Peter³^ORCID,Sénèque Olivier⁴^ORCID,Denis Yann⁵,Castanié-Cornet Marie-Pierre⁶^ORCID,Genevaux Pierre⁶^ORCID,Jakob Ursula⁷^ORCID,Reichmann Dana²^ORCID,Giudici-Orticoni Marie-Thérèse¹,Ilbert Marianne¹^ORCID

Affiliation:

1. Aix-Marseille Université, CNRS, BIP, UMR 7281, IMM, Marseille, France

2. Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram, The Hebrew University of Jerusalem, Jerusalem, Israel

3. Biometals and Biology Chemistry, Institut de Chimie (CNRS UMR7177), Université de Strasbourg, Strasbourg, France

4. Université Grenoble Alpes, CNRS, CEA, IRIG/DIESE, LCBM (UMR 5249), Grenoble, France

5. Plateforme Transcriptome, Aix-Marseille Université, CNRS, IMM-FR3479, Marseille, France

6. Laboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France

7. Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. Copper is a well-known antimicrobial and antiviral agent; however, the underlying molecular mechanisms by which copper causes cell death are not yet fully understood.

Funder

Agence Nationale de la Recherche

Conseil Régional Provence-Alpes-Côte d'Azur

HHS | NIH | National Institute of General Medical Sciences

Israel Science Foundation

LABoratoires d'EXcellence ARCANE

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03251-21